Metallothionein Stress Response
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
MT1M, MT1E, and MT2A are metallothionein isoforms — small cysteine-rich proteins that chelate heavy metals and scavenge reactive oxygen species, representing a canonical oxidative/metal stress response. IFI35 is an interferon-stimulated gene adding an inflammatory-stress component. CLU (clusterin) is a stress-inducible chaperone upregulated under proteotoxic stress. RARRES2 (chemerin) is a chemoattractant with stress-responsive expression. CADM3 and CTNNAL1 are adhesion-related. The module is dominated by metallothionein stress response genes and decreases with CD treatment, consistent with resolution of glial oxidative stress.
Genes
CADM3, CLU, CTNNAL1, IFI35, MT1E, MT1M, MT2A, RARRES2, SERPINA5, TMEM140
Most correlated modules
- MHC-I Antigen Presentation · correlation 0.78
- Glial Cytoskeletal Homeostasis · correlation 0.78
- Actin Remodeling Migration · correlation 0.76
- Type I/II Interferon Response · correlation 0.63
- Peripheral Nerve Myelination · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.