Type I/II Interferon Response
Gene co-expression module in Glial cells
| Category | Inflammation |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 15 genes have a known function matching the annotation |
Why this annotation
All hub genes are canonical interferon-stimulated genes (ISGs) and antigen presentation components: PSMB8 and PSMB9 (immunoproteasome subunits), PSME1 and PSME2 (PA28 proteasome activators), UBE2L6 (ISG15 conjugating enzyme), LY6E (ISG), HLA-F (MHC-I), IFIT3, ISG15, STAT1, GBP2, VAMP5, TAPBP (tapasin, MHC-I loading), SP100 (PML body, IFN response). This is a textbook Type I/II interferon response module driving immunoproteasome assembly and MHC class I antigen presentation. Strong upregulation in IBD inflammation (UC: 0.760, CD: 0.705), reversal with treatment. Neighbor M28 and M73 share IFN-response genes, forming a coordinated IFN axis across modules. This module is the core IFN-gamma/JAK-STAT response with immunoproteasome emphasis.
Genes
GBP2, HLA-F, IFI6, IFIT3, ISG15, LY6E, PSMB8, PSMB9, PSME1, PSME2, SP100, STAT1, TAPBP, UBE2L6, VAMP5
Most correlated modules
- IFN-gamma Effector Program · correlation 0.94
- MHC-I Antigen Presentation · correlation 0.91
- MHC-II Antigen Presentation · correlation 0.82
- Reactive Glial Activation · correlation 0.82
- Proteostasis Stress Response · correlation 0.81
- Inflammatory Cytokine Signaling · correlation 0.74
- NF-κB/IFN Inflammatory · correlation 0.73
- Actin Remodeling Migration · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.