MHC-I Antigen Presentation
Gene co-expression module in Glial cells
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes: HLA-C, HLA-A, HLA-B (MHC class I), IFITM3 (IFN-induced transmembrane protein), B2M (beta-2-microglobulin, MHC-I component), CST3 (cystatin C, lysosomal protease inhibitor), SERPING1 (complement C1 inhibitor), C1R and C1S (complement C1 subunits), IFI27 (ISG), BTN3A2 (butyrophilin, immune regulation), LGALS3BP (galectin-3 binding, immune modulation), SIGIRR (IL-1R negative regulator). This module represents MHC class I antigen presentation combined with complement activation, both classical interferon/inflammatory responses. Higher mean expression (1.742) and pct positive (62.2%) compared to M2 and M28 suggest constitutive but inflammation-amplified expression. Neighbor to M2 (immunoproteasome/ISG) and M28 (IFN-induced effectors) — together these three modules form a coherent IFN-driven antigen presentation axis. M73 specifically captures the MHC-I surface presentation and complement arm.
Genes
B2M, BTN3A2, C1R, C1S, CST3, HLA-A, HLA-B, HLA-C, IFI27, IFITM3, LGALS3BP, SERPING1, SIGIRR
Most correlated modules
- Type I/II Interferon Response · correlation 0.91
- Reactive Glial Activation · correlation 0.85
- MHC-II Antigen Presentation · correlation 0.84
- Proteostasis Stress Response · correlation 0.84
- Proteasomal Proteostasis · correlation 0.82
- Metallothionein Stress Response · correlation 0.78
- Actin Remodeling Migration · correlation 0.78
- IFN-gamma Effector Program · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.