Glial Cytoskeletal Homeostasis
Gene co-expression module in Glial cells
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include CNP (myelin-associated 2',3'-cyclic nucleotide phosphodiesterase), FEZ1 (fasciculation/axonal transport), CSRP1 (LIM-domain cytoskeletal), TBCB (tubulin folding cofactor B), and RHEB (mTOR activator). Together these represent a glial homeostatic cytoskeletal/myelination-support program. CNP is a canonical glial/Schwann cell marker. FEZ1 is involved in neuronal and glial process extension. TBCB supports microtubule biogenesis critical for glial morphology. VWA1 contributes ECM anchorage. Decreases in CD inflammation are consistent with loss of homeostatic glial state during disease.
Genes
ARL6IP5, CD99, CNP, CSRP1, FEZ1, RHEB, SCCPDH, TBCB, VWA1
Most correlated modules
- Lysosomal Sphingolipid Metabolism · correlation 0.92
- Glial Identity Homeostasis · correlation 0.89
- Glutathione Detoxification · correlation 0.88
- ER Membrane Homeostasis · correlation 0.85
- Glial Myelination Identity · correlation 0.84
- Basement Membrane Adhesion · correlation 0.83
- Antioxidant Stress Response · correlation 0.83
- Rho GTPase Signaling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.