Actin Remodeling Migration
Gene co-expression module in Glial cells
| Category | migration & adhesion |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
CALD1 (caldesmon, regulates actin-myosin interactions and stress fiber formation), SPATA13 (ASEF2, a Rac1/Cdc42 GEF that drives actin polymerization and cell migration), KTN1 (kinectin, ER-membrane cytoskeletal linker), CAST (calpastatin, endogenous calpain inhibitor controlling actin remodeling), and CD46 (complement regulator also involved in actin organization) converge on actin cytoskeletal dynamics and cell motility. GLIPR2 has roles in membrane/cytoskeletal regulation. Together this module represents a glial actin-remodeling/migratory program, consistent with enteric glia undergoing morphological plasticity.
Genes
CALD1, CAST, CD46, GLIPR2, GSTK1, KTN1, SPATA13, TCEAL4
Most correlated modules
- Basement Membrane Adhesion · correlation 0.88
- Glial RNA Homeostasis · correlation 0.80
- MHC-I Antigen Presentation · correlation 0.78
- Glial Cytoskeletal Homeostasis · correlation 0.77
- Glial Homeostatic Identity · correlation 0.76
- Peripheral Nerve Myelination · correlation 0.76
- Metallothionein Stress Response · correlation 0.76
- Glial Neuroprotective Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.