ER Translocon Activity
Gene co-expression module in Glial cells
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Top hub genes are OST4 (oligosaccharyltransferase complex subunit, N-linked glycosylation in ER), SEC61B and SEC61G (Sec61 translocon subunits, co-translational protein import into ER), PPIB (cyclophilin B, peptidyl-prolyl isomerase in ER lumen, protein folding), CALR (calreticulin, ER chaperone/calcium), NDUFA1 (Complex I subunit). Also present: MYL6 (myosin light chain, cytoskeletal), PFN1 (profilin-1, actin dynamics), ARPC2 (Arp2/3 complex, actin branching), EDF1 (elongation/transcription), SLC25A3 (mitochondrial phosphate carrier), MRPL52 (mitochondrial ribosome). The dominant program is ER translocon and co-translational protein import/folding (OST4, SEC61B, SEC61G, PPIB, CALR). Upregulated in inflammation (UC and CD) — consistent with increased ER protein processing demand. The cytoskeletal genes (MYL6, PFN1, ARPC2) may reflect coupling of secretory pathway activity with cytoskeletal remodeling in activated glia. Neighbor context: adjacent to M32 (ER membrane/OxPhos), reinforcing the ER-centric neighborhood.
Genes
ARPC2, CALR, EDF1, MRPL52, MYL6, NDUFA1, OST4, PFN1, PPIB, SEC61B, SEC61G, SLC25A3
Most correlated modules
- Proteostasis Stress Response · correlation 0.96
- Mitochondrial OxPhos Integrity · correlation 0.96
- Mitochondrial Housekeeping · correlation 0.95
- Proteasomal Proteostasis · correlation 0.94
- ER-Mitochondria Housekeeping · correlation 0.93
- Rho GTPase Signaling · correlation 0.91
- Nascent Polypeptide Translation · correlation 0.90
- ER Stress Response · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.