ER-Mitochondria Housekeeping
Gene co-expression module in Glial cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include TMED10 (GOLD domain transmembrane protein, ER/Golgi cargo receptor and anti-apoptotic), NDUFS8 and NDUFB5 (NADH:ubiquinone oxidoreductase subunits, Complex I), COX6C (cytochrome c oxidase subunit, Complex IV), LDHB (lactate dehydrogenase B, glycolysis/metabolism), CNN3 (calponin 3, cytoskeletal/actin-binding), TMBIM6 and TMBIM4 (transmembrane BAX inhibitor motif, ER stress/anti-apoptotic), PDIA3 (protein disulfide isomerase, ER quality control), TSPAN3 (tetraspanin, membrane organization), HMGN3 (chromatin). The presence of two Complex I subunits and COX6C points to mitochondrial oxidative phosphorylation, but the module also has strong ER/membrane components (TMED10, TMBIM6, TMBIM4, PDIA3). This is a mixed housekeeping module combining mitochondrial and ER membrane functions. The TMBIM family members link ER stress resistance with OxPhos, a known co-regulated axis in glia. Neighbor context: adjacent to M5 (also OxPhos-heavy) and M54 (ER translocon). This neighborhood represents a coordinated ER-mitochondria housekeeping axis.
Genes
CNN3, COX6C, HMGN3, LDHB, NDUFB5, NDUFS8, PDIA3, TMBIM4, TMBIM6, TMED10, TSPAN3
Most correlated modules
- Mitochondrial OxPhos Integrity · correlation 0.95
- Rho GTPase Signaling · correlation 0.94
- ER Translocon Activity · correlation 0.93
- ER Membrane Homeostasis · correlation 0.92
- Mitochondrial Housekeeping · correlation 0.90
- Proteostasis Stress Response · correlation 0.89
- Glial Neuroprotective Response · correlation 0.88
- Glutathione Detoxification · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.