RNA Translation Processing
Gene co-expression module in Glial cells
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
Top hub genes NPM1 (ribosome biogenesis/RNA processing), HNRNPA1 and HNRNPH3 (heterogeneous nuclear ribonucleoproteins), RBM8A (RNA-binding, exon junction complex), EEF1B2 and EEF1D (translation elongation factors) define a strong RNA processing and translation program. LDHA (glycolysis) and SLC25A5 (mitochondrial ADP/ATP translocator) support cellular metabolic activity. XBP1 is an ER stress/UPR transcription factor. TPT1 (TCTP) is translationally regulated. PFDN5 (prefoldin) assists protein folding. NAP1L1 links to chromatin/nucleosome assembly. Uniform expression and strong coherence support a constitutive translation/RNA processing housekeeping program.
Genes
CYCS, EEF1B2, EEF1D, HNRNPA1, HNRNPH3, LDHA, NAP1L1, NPM1, PFDN5, RBM8A, SLC25A5, TCEAL9, TPT1, XBP1
Most correlated modules
- ER Stress Response · correlation 0.92
- Mitochondrial Housekeeping · correlation 0.90
- Actin Cytoskeletal Organization · correlation 0.89
- Proteostasis Stress Response · correlation 0.89
- Hyaluronan-CD44 Remodeling · correlation 0.86
- Reactive Glial Activation · correlation 0.84
- COX-2/NF-κB Inflammation · correlation 0.82
- Proteostasis Stress Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.