Mitochondrial Housekeeping
Gene co-expression module in Glial cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes UQCRB, COX7C, and ATP5F1D are mitochondrial electron transport chain/OxPhos components; ATP6V1G1 is a vacuolar ATPase subunit. These co-express with general housekeeping genes (RAN, YBX1, SH3BGRL3, SUB1, SEM1, GNG5). Uniform expression across subsets, moderate mean expression, and mixed mitochondrial/nuclear housekeeping identity indicate a general cellular metabolism and OxPhos housekeeping program. The mild CD-inflammation upregulation may reflect increased metabolic demand in reactive glia.
Genes
ATP5F1D, ATP6V1G1, COX7C, GNG5, RAN, SEM1, SH3BGRL3, ST3GAL4, SUB1, TRIR, UQCRB, YBX1
Most correlated modules
- ER Translocon Activity · correlation 0.95
- Proteostasis Stress Response · correlation 0.94
- Nascent Polypeptide Translation · correlation 0.92
- Mitochondrial OxPhos Integrity · correlation 0.92
- Rho GTPase Signaling · correlation 0.91
- ER-Mitochondria Housekeeping · correlation 0.90
- RNA Translation Processing · correlation 0.90
- ER Stress Response · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.