Proteostasis Stress Response
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
This module contains a mix of housekeeping-type genes including mitochondrial complex components (NDUFS5, COX7B, ATP6V0E1, ATP5MG), a proteasome subunit (PSMA3), RNA splicing factor (SNRPB2), copper chaperone (ATOX1), and TIMP1. The module is upregulated in inflammation (UC and CD) but shows uniform expression across subsets. The genes collectively reflect general cellular maintenance programs — protein quality control, energy metabolism, and stress response. The co-expression of POMP (proteasome maturation), PSMA3, TIMP1, IFITM2, and CYSTM1 alongside mitochondrial genes suggests a basal stress/proteostasis response. TIMP1 is notable as an inflammation-associated ECM regulator. Given the moderate inflammation delta and the broad mix of housekeeping-adjacent stress genes, this module best represents a general cellular stress/proteostasis response. Neighbor context: this module is topologically near M41, M2, M73, M28, M72, and M9, all of which show inflammatory upregulation — consistent with this being a milder, basal stress-response arm of the same inflammatory network.
Genes
ATOX1, ATP5MG, ATP6V0E1, C19orf53, C4orf3, COX7B, CYSTM1, GUK1, IFITM2, NDUFS5, POMP, PSMA3, RTRAF, S100A16, SNRPB2, TIMP1
Most correlated modules
- ER Translocon Activity · correlation 0.96
- Mitochondrial Housekeeping · correlation 0.94
- Proteasomal Proteostasis · correlation 0.93
- Mitochondrial OxPhos Integrity · correlation 0.92
- Reactive Glial Activation · correlation 0.90
- ER-Mitochondria Housekeeping · correlation 0.89
- Nascent Polypeptide Translation · correlation 0.88
- Reactive Glial Activation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.