RNASE1 — Ribonuclease A family member 1, pancreatic
RNASE1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNASE1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia-IFN Endothelial Endothelial cell development | BCAM, CRIP2, EPAS1, FES, HEG1, IFI27, IFITM1, LIMA1 +8 more | View in SCUBA |
| Glial cells | Myelinating Schwann Cell Myelination | ALDH1A1, ARHGAP15, CXCL12, FCGR2B, MPZ, MXRA8, NTM, PRNP +1 more | View in SCUBA |
| Goblet cells | Secretory Lineage Specification Epithelial development | ANXA13, ATOH1, CA8, CBFA2T2, DLL1, DYRK4, FOXA2, FRA10AC1 +12 more | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Lysosomal & pahgocytosis | AP2A2, BLVRB, CD163, FAH, FCGRT, HTRA1, MKKS, MYO7A +6 more | View in SCUBA |
About the gene
| Synonyms | RAC1, RNS1 |
|---|---|
| Chromosome | 14: 20801228-20802855 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Endonuclease, Hydrolase, Lyase, Nuclease |
Function
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.