BMP Signaling Response
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
ID2 and ID3 are BMP-responsive inhibitors of differentiation (Inhibitor of DNA binding proteins), closely related to ID1 in M64, suggesting shared BMP/Notch signaling neighborhood. PDK4 drives metabolic reprogramming (inhibits glucose oxidation), GSTA1/GSTA4 mediate glutathione-dependent detoxification, CAMK2N1 modulates calcium signaling. ZBTB10 and CCND2 add transcriptional and cell cycle context. Strong downregulation during inflammation with partial recovery indicates a homeostatic BMP-signaling and metabolic adaptation program in healthy goblet cells.
Genes
CAMK2N1, CCND2, EIF4A2, GSTA1, GSTA4, ID2, ID3, PDK4, ZBTB10
Most correlated modules
- Notch Target Response · correlation 0.75
- mRNA Stability Control · correlation 0.73
- Colonocyte Differentiation Program · correlation 0.71
- Goblet Cell Identity · correlation 0.70
- Epithelial Maintenance · correlation 0.63
- Goblet Cell Differentiation · correlation 0.62
- Immediate Early Gene · correlation 0.62
- Co-translational Chaperone · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.