RNA Splicing
Gene co-expression module in Goblet cells
| Category | RNA processing & translation |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
HNRNPU, HNRNPH1 are heterogeneous nuclear ribonucleoproteins with core roles in pre-mRNA processing, splicing, and export. FUS is an RNA-binding protein critical for splicing and transcription. LUC7L3 is a splicing factor. ARGLU1 is an arginine/glutamate-rich splicing co-activator. C6orf62 associates with RNA processing complexes. NOP53 is a nucleolar protein involved in ribosome biogenesis. EPHB3 is an outlier (Eph receptor kinase) but may co-regulate with RNA programs. The module is strongly enriched for RNA splicing and processing factors.
Genes
ARGLU1, C6orf62, EPHB3, FUS, HNRNPH1, HNRNPU, LUC7L3, NOP53
Most correlated modules
- Chromatin Remodeling · correlation 0.73
- Chromatin Remodeling · correlation 0.72
- hnRNP RNA Processing · correlation 0.71
- Colonocyte Differentiation Program · correlation 0.61
- Nuclear Architecture · correlation 0.59
- BMP Signaling Response · correlation 0.54
- Notch Target Response · correlation 0.52
- Secretory Lineage Specification · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.