HES6 — Hes family bHLH transcription factor 6
HES6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HES6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Secretory Lineage Specification Epithelial development | ANXA13, ATOH1, CA8, CBFA2T2, DLL1, DYRK4, FOXA2, FRA10AC1 +12 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Heme Synthesis Erythropoietic | BLVRB, HBQ1, MPC2, MPST, REXO2, SMIM10, TMEM14B, TMEM14C +2 more |
About the gene
| Synonyms | bHLHb41 |
|---|---|
| Chromosome | 2: 238238267-238240662 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, Repressor |
| Biological process | Differentiation, Transcription, Transcription regulation |
Function
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.