Mucin O-Glycosylation
Gene co-expression module in Goblet cells
| Category | Mucus production & secretion |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes ASPH, RAB2A, ST6GALNAC1, SSR2, SEC22B, and CKAP4 define an ER-to-Golgi vesicular trafficking and O-glycosylation program. ST6GALNAC1 (sialyltransferase for mucin O-glycans), UGDH (UDP-glucuronate for glycan synthesis), ASPH (ER hydroxylase), SSR2 (ER translocon), and RAB2A/SEC22B (ER-Golgi SNARE/vesicle trafficking) collectively describe the goblet cell secretory machinery for mucin glycosylation. IL13RA1 links this program to IL-13-driven goblet cell differentiation. The disease associations (increased in UC inflammation, decreased in remission) are consistent with heightened mucin biosynthetic activity during active colitis.
Genes
ACLY, ASPH, C9orf152, CKAP4, ESRP1, FABP2, IL13RA1, PLPP5, RAB2A, SEC22B, SMIM14, SSR2, ST6GALNAC1, TPD52, TPM1, UBXN4, UGDH
Most correlated modules
- Ubiquitin Protein Homeostasis · correlation 0.74
- Mucin O-Glycosylation · correlation 0.73
- ER Protein Translocation · correlation 0.71
- Goblet Secretory Identity · correlation 0.71
- Secretory Lineage Specification · correlation 0.71
- ERAD ER Homeostasis · correlation 0.65
- Adhesion & Transport · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.