Goblet Cell Identity
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
FOXP1 is a transcription factor important for goblet cell differentiation and intestinal epithelial identity. NFAT5 (TonEBP) is an osmotic stress-responsive transcription factor relevant to ion/water homeostasis in the colon. SLC4A7 is a sodium-bicarbonate cotransporter. ITPR2 mediates calcium release important for mucus secretion signaling in goblet cells. NEDD4L is a ubiquitin ligase regulating ion channel turnover. WFDC2 is a secreted protease inhibitor expressed by secretory epithelia. HOXB13 is a posterior HOX factor expressed in distal colon. KCTD12 modulates GABA-B receptor signaling. The module reflects goblet/secretory epithelial identity with ion homeostasis. Suppressed during CD inflammation.
Genes
CELF2, FOXP1, FRYL, GPRIN3, HOXB13, ITPR2, KCTD12, NEDD4L, NFAT5, PLXDC2, PRAC1, SLC38A2, SLC4A7, WFDC2
Most correlated modules
- BMP Signaling Response · correlation 0.70
- Secretory Lineage Specification · correlation 0.66
- Chromatin Remodeling · correlation 0.64
- Ion Transport Homeostasis · correlation 0.60
- Nuclear Architecture · correlation 0.59
- mRNA Stability Control · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.