Oxidative Phosphorylation
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are almost entirely mitochondrial respiratory chain subunits: ATP5PO (ATP synthase, Complex V), UQCRH and UQCRB (ubiquinol-cytochrome c reductase, Complex III), COX7C, COX6A1, COX4I1, COX6C (cytochrome c oxidase subunits, Complex IV), NDUFB5 (NADH dehydrogenase, Complex I), ATP5MG (Complex V). ECH1 is a mitochondrial fatty acid oxidation auxiliary enzyme. This is a tightly core-coherent, high-expression, high-detection module that is uniformly expressed and downregulated in inflammation with partial treatment recovery. It represents the canonical oxidative phosphorylation / electron transport chain program. Neighbor context: the entire batch neighborhood is mitochondrial; M58 is the purest OxPhos module with near-exclusive ETC subunit composition.
Genes
ATP5MG, ATP5PO, COX4I1, COX6A1, COX6C, COX7C, ECH1, NDUFB5, UQCRB, UQCRH
Most correlated modules
- Glutathione Detoxification · correlation 0.79
- Mitochondrial Metabolism · correlation 0.79
- Co-translational Chaperone · correlation 0.76
- Mitochondrial Homeostasis · correlation 0.74
- Oxidative Phosphorylation · correlation 0.66
- Actin Dynamics · correlation 0.62
- Epithelial Membrane Identity · correlation 0.59
- Mitochondrial OxPhos · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.