Mitochondrial Homeostasis
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include PEBP1 (phosphatidylethanolamine-binding protein, involved in Raf kinase inhibition and mitochondrial function), COX5A (cytochrome c oxidase subunit), PHB2 (prohibitin 2, mitochondrial inner membrane scaffold), PPIA (cyclophilin A, protein folding/chaperone), PRDX2 (peroxiredoxin 2, ROS scavenging), SNRPE (snRNP component), BZW2 (translation factor), and MPST (mitochondrial sulfur metabolism). The module is downregulated in inflammation and recovers with treatment/remission, consistent with a housekeeping/mitochondrial homeostasis program. COX5A and PHB2 are mitochondrial; PRDX2 is antioxidant. However, the mix of translation (PPIA, BZW2), snRNP (SNRPE), and mitochondrial genes suggests a general housekeeping/stress-resilience program. Neighbor context: M53 and M58 are strongly mitochondrial/OxPhos; M67 shares COX5A and mitochondrial flavor but also includes non-OxPhos housekeeping genes. Given the dominant mitochondrial hub genes and the shared neighborhood, the best label is mitochondrial homeostasis/housekeeping.
Genes
BZW2, COX5A, MPST, PEBP1, PHB2, PPIA, PRDX2, SNRPE
Most correlated modules
- Mitochondrial Metabolism · correlation 0.84
- Chromatin RNA Regulation · correlation 0.84
- Lipid Redox Homeostasis · correlation 0.83
- mRNA Translation Initiation · correlation 0.83
- hnRNP RNA Processing · correlation 0.80
- SR Splicing Factors · correlation 0.78
- RNA Decay Processing · correlation 0.75
- Oxidative Phosphorylation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.