Co-translational Chaperone
Gene co-expression module in Goblet cells
| Category | Protein processing & ER |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
NACA and BTF3 form the nascent polypeptide-associated complex (NAC), functioning co-translationally as chaperones. PFDN5 is a prefoldin subunit (chaperone complex). FTL and FTH1 are ferritin subunits (iron storage/housekeeping). ATP5MC2 and HIGD2A/TOMM7 represent mitochondrial housekeeping. COMMD6 participates in copper/NF-kB regulation. Core coherence and uniform expression at very high detection. Neighbor to M97 (translation module) - the shared co-translational chaperone theme (NACA/BTF3) explains the topological proximity. Inflammation downregulation mirrors M97, confirming housekeeping suppression in IBD.
Genes
ATP5MC2, BTF3, COMMD6, FTH1, FTL, HIGD2A, NACA, PFDN5, TOMM7
Most correlated modules
- mRNA Translation Initiation · correlation 0.83
- Oxidative Phosphorylation · correlation 0.76
- Epithelial Membrane Identity · correlation 0.76
- Mitochondrial Homeostasis · correlation 0.71
- Epithelial Maintenance · correlation 0.67
- Colonocyte Differentiation Program · correlation 0.61
- Notch Target Response · correlation 0.60
- BMP Signaling Response · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.