Mitochondrial Metabolism
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRDX3 (mitochondrial peroxiredoxin, ROS detoxification), ATP5F1B and ATP5PB (ATP synthase subunits, Complex V), SUCLG1/SUCLG2 (succinyl-CoA ligase, TCA cycle), HADH and ECHS1 (fatty acid beta-oxidation enzymes), COTL1 (actin-binding, but also mitochondrial associations). CD99 and GPR160 are less obviously mitochondrial. The module is strongly downregulated in inflammation and recovers with CD treatment. The core program is mitochondrial metabolism: TCA cycle (SUCLG1/2), OxPhos (ATP5F1B, ATP5PB), fatty acid oxidation (HADH, ECHS1), and mitochondrial ROS defense (PRDX3). Neighbor context: sits alongside M58 (classic OxPhos) and M67 (mixed mitochondrial/housekeeping), confirming a mitochondrial metabolic neighborhood. M53 emphasizes TCA and FAO more than pure OxPhos.
Genes
ATP5F1B, ATP5PB, CD99, COTL1, ECHS1, GPR160, HADH, PRDX3, SUCLG1, SUCLG2
Most correlated modules
- Mitochondrial Homeostasis · correlation 0.84
- Glutathione Detoxification · correlation 0.80
- Oxidative Phosphorylation · correlation 0.79
- Anti-inflammatory Lipid Signaling · correlation 0.76
- Colonocyte Metabolic Defense · correlation 0.74
- mRNA Translation Initiation · correlation 0.71
- Lipid Redox Homeostasis · correlation 0.70
- Chromatin RNA Regulation · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.