Oxidative Phosphorylation
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
All hub genes are canonical OXPHOS/electron transport chain components: UQCR10 and UQCRQ (Complex III), COX8A, COX7A2, COX7B (Complex IV/cytochrome c oxidase), ATP5MF (Complex V/ATP synthase), SLC25A5 (ANT2, mitochondrial ADP/ATP carrier), NDUFC1/NDUFC2 (Complex I), CYCS (cytochrome c), MPC1/MPC2 (mitochondrial pyruvate carrier). Strong coherence, high detection rate (92%). Downregulated in both UC and CD inflammation, restored in UC remission — consistent with loss and recovery of mitochondrial respiratory function in colitis.
Genes
ATP5MF, COX7A2, COX7B, COX8A, CYCS, MPC1, MPC2, NDUFC1, NDUFC2, SLC25A5, UQCR10, UQCRQ
Most correlated modules
- Mitochondrial OxPhos · correlation 0.85
- Proteasome Complex · correlation 0.79
- Ubiquitin-Proteasome Degradation · correlation 0.77
- ER Protein Processing · correlation 0.75
- Sterol Biosynthesis · correlation 0.73
- Electron Transport Chain · correlation 0.71
- Basal Transcription · correlation 0.68
- Glutathione Detoxification · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.