Mitochondrial OxPhos
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes ATP5MC3, ATP5PF, ATP5MC1 are ATP synthase (Complex V) subunits; NDUFB2 and NDUFA12 are NADH dehydrogenase (Complex I) subunits; MTCH2 is a mitochondrial carrier; DBI is involved in lipid/mitochondrial metabolism; TPI1 (triosephosphate isomerase) is a glycolytic enzyme but frequently co-expressed with OxPhos genes. The module is uniformly expressed, strongly coherent, and decreases with inflammation while recovering in remission — consistent with a housekeeping mitochondrial energy program. Neighboring modules M90 and M54 also strongly feature OxPhos/Complex I genes, confirming this neighborhood represents mitochondrial respiration programs.
Genes
ATP5MC1, ATP5MC3, ATP5PF, DBI, MTCH2, NDUFA12, NDUFB2, TPI1
Most correlated modules
- Oxidative Phosphorylation · correlation 0.85
- Electron Transport Chain · correlation 0.78
- Mitochondrial Biogenesis · correlation 0.77
- Glutathione Detoxification · correlation 0.74
- Spliceosome Assembly · correlation 0.73
- Mitochondrial OxPhos · correlation 0.73
- Ubiquitin-Proteasome Degradation · correlation 0.71
- Sterol Biosynthesis · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.