Actin Dynamics
Gene co-expression module in Goblet cells
| Category | Cytoskeletal |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
The top hub genes MYL12A (myosin regulatory light chain), TMSB10 (thymosin beta-10, actin monomer sequestration), CFL1 (cofilin-1, actin filament severing), and ABRACL (actin-binding Rho activating C-terminal like, regulates Arp2/3 branching) form a coherent actin dynamics/cytoskeletal program. SRI (sorcin) is a calcium-binding protein linked to vesicle trafficking. NDUFB4 and NDUFS5 are NADH:ubiquinone oxidoreductase (Complex I) subunits suggesting mitochondrial co-expression. OCIAD2 is a mitochondrial inner membrane protein. SRP14 contributes to co-translational targeting. The high expression and detection rate (1.503 mean, 89.4% pct positive) indicate a constitutive housekeeping program. The actin remodeling genes (TMSB10, CFL1, MYL12A, ABRACL) dominate the top hubs; the mitochondrial genes are secondary. Neighbor context with M16 (also cytoskeletal) supports a cytoskeletal housekeeping identity.
Genes
ABRACL, CD24, CFL1, MYL12A, NDUFB4, NDUFS5, OCIAD2, PIN4, RTRAF, SRI, SRP14, TMSB10
Most correlated modules
- Lipid Redox Homeostasis · correlation 0.73
- Epithelial Maintenance · correlation 0.72
- Adhesion & Transport · correlation 0.65
- Progenitor Identity Program · correlation 0.63
- Oxidative Phosphorylation · correlation 0.62
- Glutathione Detoxification · correlation 0.61
- Proteasome Complex · correlation 0.59
- Epithelial Membrane Identity · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.