Nucleotide Metabolism Stress
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module has only mild inflammation association (delta ~0.2 in both UC and CD) and does not strongly reverse with treatment or remission. Hub genes: TYMP (thymidine phosphorylase, nucleotide metabolism/angiogenesis), CEBPD (C/EBP-delta, acute phase/inflammatory transcription factor), APRT (adenine phosphoribosyltransferase, purine salvage), CYB5A (cytochrome b5, ER redox), NME3 (nucleoside diphosphate kinase), PNKD (paroxysmal nonkinesigenic dyskinesia, mitochondrial), LY6E (interferon-stimulated, lymphocyte antigen), NFKBIZ (NF-kB inhibitor zeta, inflammatory modulator). The combination of nucleotide metabolism (TYMP, APRT, NME3), an inflammatory transcription factor (CEBPD), and mild inflammation response suggests a low-grade stress/metabolic adaptation module. The moderate coherence and weak membership of several genes indicate a mixed program. The most parsimonious label is nucleotide metabolism with mild inflammatory co-regulation.
Genes
APRT, CEBPD, CYB5A, LY6E, NFKBIZ, NME3, PNKD, TYMP
Most correlated modules
- Mucosal Innate Defense · correlation 0.64
- Pyroptosis Stress Response · correlation 0.56
- Mitochondrial Biogenesis · correlation 0.54
- DUOX2 Epithelial Inflammation · correlation 0.50
- MHC Class II Antigen Presentation · correlation 0.50
- NF-kB Inflammatory Signaling · correlation 0.47
- Secreted Antimicrobials · correlation 0.41
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.