DUOX2 Epithelial Inflammation
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
This module has the highest inflammation delta in the batch for UC (1.570) and significant CD (0.999), with clear remission reversal. Hub genes are strongly linked to innate inflammatory and antiviral programs: DUOX2 and DUOXA2 (dual oxidase system, major IBD inflammation marker in epithelium, reactive oxygen species production), BIRC3 (NF-kB target, anti-apoptotic IAP), ISG15 (interferon-stimulated gene), RNF213 (interferon-induced ubiquitin ligase), DUSP4 (MAPK phosphatase, anti-inflammatory feedback), SAA1 (acute phase reactant), IL2RG (common gamma chain cytokine receptor), IL32 (pro-inflammatory cytokine), AKAP13 (NF-kB scaffold). DUOX2/DUOXA2 are the hallmark epithelial IBD inflammation genes. This module is a tight, coherent epithelial inflammatory program centered on DUOX2-mediated oxidative stress and NF-kB/IFN co-activation.
Genes
AKAP13, BIRC3, DUOX2, DUOXA2, DUSP4, IL2RG, IL32, ISG15, RNF213, SAA1
Most correlated modules
- Inflammatory goblet response · correlation 0.77
- MHC Class I Antigen Presentation · correlation 0.71
- Basement Membrane Remodeling · correlation 0.63
- NF-kB Inflammatory Signaling · correlation 0.59
- Mucosal Antibacterial Defense · correlation 0.51
- Nucleotide Metabolism Stress · correlation 0.50
- MHC Class II Antigen Presentation · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.