Mitotic Spindle Assembly
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 43 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 43 genes have a known function matching the annotation |
Why this annotation
Hub genes HAUS1, MZT1, MZT2B are augmin/γ-TuRC complex members for spindle microtubule nucleation; RANBP1 regulates RAN GTPase in mitosis; TUBB encodes β-tubulin; BUB3 is a spindle assembly checkpoint component; CENPX is a centromere protein; NUP37 is a nuclear pore component involved in mitotic spindle assembly. Additional genes include RNA splicing factors (LSM2, LSM4, SNRNP25, MAGOHB) and H2AZ1 histone variant. The dominant program is mitotic spindle assembly, all strongly enriched in prolif_mac.
Genes
ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX, DCTPP1, EXOSC9, GGCT, H2AZ1, H2AZ2, HAUS1, HMGB1, HMGN2, HPF1, HPRT1, IFT25, LDHB, LSM2, LSM4, LSM5, MAGOHB, MRPL17, MRPL37, MZT1, MZT2A, MZT2B, NAA38, NUDT1, NUP37, PPIH, PRRC2A, RAD21, RANBP1, RPA3, SIVA1, SNRNP25, SNRNP40, TRIOBP, TUBB, UQCC2
Most correlated modules
- Replication Chromatin Assembly · correlation 0.96
- Spliceosomal snRNP · correlation 0.93
- Complex I / NADH Dehydrogenase · correlation 0.88
- DNA Replication Metabolism · correlation 0.88
- G1/S Transition · correlation 0.88
- Mitotic Chromosome Condensation · correlation 0.87
- Oxidative Phosphorylation · correlation 0.85
- S-phase DNA Replication · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.