DNA Replication Metabolism
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
RPA1 (replication protein A), RFC1 (replication factor C), PARP1 (DNA repair/replication), NUCKS1 (chromatin remodeling at replication forks), and DCK (deoxycytidine kinase for nucleotide salvage) anchor a DNA replication/repair program. MTHFD1 supports one-carbon/folate metabolism for nucleotide biosynthesis. FADS1, HACD3, AGPAT5 indicate lipid biosynthesis supporting membrane production for dividing cells. ICMT methylates RAS-family proteins. TP53 and IDH2 are also present. The module combines DNA replication machinery with biosynthetic support, all enriched in prolif_mac.
Genes
AGPAT5, CBX1, DCK, FADS1, HACD3, HADH, ICMT, IDH2, MTHFD1, NUCKS1, NUP85, PARP1, RFC1, RPA1, SAMD1, SLC16A1, SLC29A1, TM7SF3, TMEM109, TP53
Most correlated modules
- Centrosome & DNA Repair · correlation 0.94
- Replication Chromatin Assembly · correlation 0.89
- Mitotic Spindle Assembly · correlation 0.88
- G1/S Transition · correlation 0.88
- Macrophage Proliferation · correlation 0.84
- S-phase DNA Replication · correlation 0.82
- Mitotic Chromosome Condensation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.