TFDP1 — Transcription factor Dp-1
TFDP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TFDP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ACTL6A, LMNB1, RRM2, SAE1, SMC2, SSRP1, TYMS, UBE2T +2 more | View in SCUBA |
| CD8⁺ T cells | Replication Licensing Cell cycle | ACYP1, DDB2, DSN1, GMNN, HIRIP3, ITGB3BP, LSM3, MAGOHB +8 more | View in SCUBA |
| Endothelial | Nuclear Transport Housekeeping | AAMDC, ANP32B, CBX5, CDK4, CKAP4, COMMD4, COQ2, CSE1L +18 more | View in SCUBA |
| Macrophages | G1/S Transition Cell cycle | ARL6IP6, BTG3, CNOT9, HAT1, HAUS2, PAICS, SFXN1, SLBP +1 more | View in SCUBA |
About the gene
| Synonyms | DILC, Dp-1, DP1, DRTF1 |
|---|---|
| Chromosome | 13: 113584721-113641473 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Cell cycle, Transcription, Transcription regulation |
Function
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.