TSPYL2 — TSPY like 2

TSPYL2 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TSPYL2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6 +13 more	View in SCUBA
CD4⁺ T cells	Glucocorticoid Immunoregulation Immune regulation	AHNAK, BTG1, CRIP1, GGNBP2, IDS, INSIG1, IRS2, JUND +11 more	View in SCUBA
Endothelial	Integrated Stress Response Stress	ARL5B, ATF3, CCNL1, CD83, CDKN1A, DDIT3, ICAM4, IRF1 +3 more	View in SCUBA
Fibroblasts	Co-transcriptional RNA Processing Housekeeping	FUS, IFRD1, INTS6, PCF11, PPP1R10, RSRP1, YME1L1	View in SCUBA
Gamma-delta T cells	Chromatin Epigenetic Regulation DNA/chromatin regulation	ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more
Glial cells	Anti-proliferative mRNA Decay Stress	ABHD5, BCL6, EIF4A1, FUS, GADD45A, MAT2A, PLK2, RBBP6 +4 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	Notch TGF-β Endothelial endothelial development	ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, GPBP1 +11 more	View in SCUBA
Macrophages	Stress Response Transcription Stress	AHR, C11orf96, CBX6, FAM110A, FN3K, GADD45A, LACC1, LPAR6 +8 more	View in SCUBA
Mucosal-associated invariant T cell	Splicing Regulation RNA processing & translation	AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R +9 more
Natural Killer cells	Glucocorticoid Response Immune regulation	AREG, ARF6, BCLAF1, BEX2, BEX4, ELF1, ELL2, EPC1 +11 more	View in SCUBA

About the gene

Synonyms	CDA1, CINAP, CTCL, DENTT, HRIHFB2216, SE20-4, TSPX
Chromosome	X: 53082367-53088540
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Chromatin regulator
Biological process	Cell cycle, Transcription, Transcription regulation

Function

Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.