Vascular Quiescence
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes KLF4 and KLF2 are canonical flow/shear-stress-responsive and quiescence-promoting transcription factors in vascular cells. ID2 is an inhibitor of differentiation associated with vascular quiescence. PLK2 is an immediate-early gene induced by activity/stress. SAT1 is a polyamine catabolism enzyme linked to growth arrest. MYLIP (MIR) is a cholesterol-responsive E3 ligase. RHOB is a stress-responsive Rho GTPase. HBEGF is an EGF family growth factor induced by mechanical/hypoxic stress. ZFP36L2 is an mRNA destabilizer that promotes quiescence. MIDN (midnolin) is involved in proteasomal stress. The module is significantly down in inflammation and up in UC remission, consistent with a vascular quiescence/homeostasis program lost during inflammation. KLF2/KLF4 are the defining hub genes of endothelial/pericyte quiescence.
Genes
HBEGF, ID2, KLF2, KLF4, MIDN, MYLIP, PLK2, RHOB, SAT1, ZFP36L2
Most correlated modules
- Proteotoxic Stress Response · correlation 0.90
- EMT-like Remodeling · correlation 0.88
- Immediate Early Gene · correlation 0.81
- NF-κB Inflammatory Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.