RHOB — Ras homolog family member B

RHOB belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RHOB's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6 +13 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	DNAJA4, DNAJB1, DNAJB4, HSPA1A, HSPA1B, HSPA6, HSPB1, PLIN2 +3 more	View in SCUBA
Endothelial	Notch Arterial Identity Endothelial cell development	ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2 +14 more	View in SCUBA
Fibroblasts	Fibroblast Quiescence Housekeeping	BTG1, EIF1, EIF4A2, FNIP1, ID2, KLF2, KLF4, SRSF5 +5 more	View in SCUBA
Gamma-delta T cells	Stress Epigenetic Silencing DNA/chromatin regulation	ALKBH5, ANKHD1, EPC2, FAM53C, MXD1, NEU1, OTUD4, PHF1 +8 more
Goblet cells	NF-κB Stress Response Stress	ATF3, CCNL1, EGR3, IER3, MAFF, MYADM, NFKBIA, NR4A1 +1 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more	View in SCUBA
Monocytes	ER Stress Response Stress	CDKN1B, CFAP20, DDIT3, GIMAP5, HSPA5, KLF2, KLF4, ODC1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	TCR-Induced Early Response TCR Signaling	ATF3, EGR1, GLA, HMGCS1, IER3, NR4A1, NUP58, PPP1R15B +3 more
Natural Killer cells	Inducible HSP70 Stress Stress	BAG3, DNAJB1, FKBP4, HSPA1A, HSPA1B, HSPA4, HSPA6, HSPB1 +2 more	View in SCUBA
Pericytes	Vascular Quiescence Developmental	HBEGF, ID2, KLF2, KLF4, MIDN, MYLIP, PLK2, SAT1 +1 more	View in SCUBA
Smooth muscle cells	Immediate Early Response Stress	ATF3, BTG1, BTG2, CDKN1A, EGR1, FOS, GADD45B, HES1 +7 more	View in SCUBA

About the gene

Synonyms	ARH6, ARHB, MST081, RHOH6
Chromosome	2: 20447074-20449440
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins
Molecular function	Developmental protein
Biological process	Angiogenesis, Apoptosis, Cell adhesion, Differentiation, Protein transport, Transport

Function

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.