EMT-like Remodeling
Gene co-expression module in Pericytes
| Category | ECM remodeling |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include RND1 (Rho GTPase promoting cell rounding/detachment), SNAI1 (master EMT transcription factor), TNFRSF10D (decoy TRAIL receptor, anti-apoptotic), LDLR and INSIG1 (cholesterol/lipid metabolism), B3GNT5 (glycosyltransferase), APOLD1 (vascular stress-response gene), and RALGDS (Ras effector). SNAI1 and RND1 together strongly suggest an EMT/cytoskeletal remodeling program. LDLR/INSIG1 co-occurrence suggests lipid-metabolic reprogramming accompanying EMT. APOLD1 is induced by vascular stress. The module is up in UC remission, suggesting pericyte plasticity during tissue repair. Neighbor M54 (KLF2/KLF4 quiescence) and M47 (inflammatory TFs) provide context: M71 may represent a transitional/mesenchymal state between quiescence and inflammation.
Genes
APOLD1, B3GNT5, C2CD4B, CFAP20, FAM43A, INSIG1, LDLR, RALGDS, RND1, SNAI1, TNFRSF10D
Most correlated modules
- NF-κB Inflammatory Response · correlation 0.92
- Arterial Notch Signaling · correlation 0.92
- Vascular Quiescence · correlation 0.88
- Proteotoxic Stress Response · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.