SAT1 — Spermidine/spermine N1-acetyltransferase 1

SAT1 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SAT1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Early Response Stress Stress	ANKRD37, DNAJA1, GTF2B, NR4A2, SIK1, SOCS3, UBB, UBC	View in SCUBA
CD4⁺ T cells	TNF/NF-kB activation TCR/AP1/NFKb pathway	BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, PMAIP1 +6 more	View in SCUBA
CD8⁺ T cells	Tc17 Survival Program Tc17 program	CCL20, DDX5, IRF1, MAF, MCL1, TNFAIP3, TNFRSF4	View in SCUBA
Endothelial	Notch Arterial Identity Endothelial cell development	ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2 +14 more	View in SCUBA
Enterocytes	Surface colonocyte differentiation Epithelial development	AGR3, ATP1B1, BMP3, CLDN3, DSP, KLF5, KRT20, NEURL1B +2 more	View in SCUBA
Fibroblasts	NF-κB Stress Response Inflammatory	EGR3, NAMPT, NCOA7, NFIL3, PHLDA1, PHLDA2, SLC20A1, SOD2 +3 more	View in SCUBA
Gamma-delta T cells	ER Proteotoxic Stress Stress	ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB +13 more
Glial cells	Inflammatory Activation Response Inflammation	ANGPTL4, C11orf96, CD83, CEBPD, ENY2, GEM, IDI1, IRF9 +3 more	View in SCUBA
Goblet cells	Mucosal Antibacterial Defense Immune function	ANXA11, B3GNT7, C15orf48, C19orf33, CLIC1, CSTB, CYSTM1, ELOB +8 more	View in SCUBA
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1 +12 more	View in SCUBA
Mucosal-associated invariant T cell	Dissociation Stress Response Stress	DUSP1, EIF1, FOS, H3-3B, IER5, SRSF3, SRSF7
Neutrophils	Neutrophil Survival Program Inflammatory	B2M, BCL2A1, CEBPB, EIF1, FTH1, FTL, H3-3A, H3-3B +2 more
Pericytes	Vascular Quiescence Developmental	HBEGF, ID2, KLF2, KLF4, MIDN, MYLIP, PLK2, RHOB +1 more	View in SCUBA
Smooth muscle cells	IFN-gamma/NF-kB Response Inflammation	ATP6V0B, CCDC71L, CFLAR, CHI3L2, EVA1B, GBP1, GBP2, HSPA8 +11 more	View in SCUBA

About the gene

Synonyms	SAT, SSAT
Chromosome	X: 23783173-23786210
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Acyltransferase, Transferase

Function

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also acts on 1,3- diaminopropane and 1,5-diaminopentane.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.