HBEGF — Heparin binding EGF like growth factor
HBEGF belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HBEGF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Notch Arterial Identity Endothelial cell development | ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2 +14 more | View in SCUBA |
| Fibroblasts | Hypoxia-driven EMT Stress | ARC, CITED2, CSKMT, DDIT4, FAM43A, FAM53C, HEXIM1, IER5L +7 more | View in SCUBA |
| Goblet cells | EGF-Driven Wound Repair Epithelial development | AREG, ARL14, C3orf52, CXCL8, F11R, NCOA7, RAP2B, RHPN2 +1 more | View in SCUBA |
| Lymphatic endothelial | DNA Damage Response DNA/chromatin regulation | BRD2, BTG2, CITED2, H2AX, HEXIM1, INTS6, MAFB, NR4A1 +7 more | View in SCUBA |
| Monocytes | Integrated Stress Response Stress | CDKN1A, CSRNP1, EIF2AK3, KLF10, MAFF, PIM3, TIPARP | View in SCUBA |
| Pericytes | Vascular Quiescence Developmental | ID2, KLF2, KLF4, MIDN, MYLIP, PLK2, RHOB, SAT1 +1 more | View in SCUBA |
About the gene
| Synonyms | DTR, DTS, HEGFL |
|---|---|
| Chromosome | 5: 140332843-140346603 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Growth factor, Heparin-binding, Receptor |
Function
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.