Vascular Junction Adhesion
Gene co-expression module in Pericytes
| Category | Migration & adhesion |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes ESAM (endothelial selective adhesion molecule), SLC44A2 (choline transporter enriched in vascular cells), FYN (Src-family kinase at cell junctions), PREX1 (Rac GEF downstream of PI3K at cell contacts), VAMP5 (vesicular trafficking), and VOPP1 (vesicular protein) collectively point to a pericyte-endothelial adhesion and junction maintenance program. ESAM is a direct marker of vascular cell-cell junctions. FYN and PREX1 mediate downstream signaling at adhesion complexes. The module is core-coherent with uniform pericyte expression and upregulated in UC remission, consistent with restoration of vascular barrier integrity.
Genes
ABHD17A, CCDC85B, CDC37, ESAM, FYN, HECW2, PREX1, SELENON, SLC44A2, VAMP5, VOPP1
Most correlated modules
- G1 Cell Cycle Entry · correlation 0.98
- YAP/TAZ Mechanosensing · correlation 0.98
- BMP Receptor Signaling · correlation 0.97
- Actin-ERM Migration · correlation 0.96
- Vascular Pericyte Identity · correlation 0.96
- Angiogenic Receptor Signaling · correlation 0.96
- Rho GTPase Signaling · correlation 0.96
- Vascular Permeability · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.