Angiogenic Receptor Signaling
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes KDR (VEGFR2, the primary angiogenic VEGF receptor), ROBO4 (roundabout-4, vascular-specific guidance receptor stabilizing vasculature), EPHB4 (EphB4, venous identity marker and angiogenic receptor), and PLXNA2 (plexin A2, semaphorin co-receptor for vascular guidance) define a vascular guidance and angiogenic receptor program. SLCO2A1 (prostaglandin transporter) and RASGRP3 (Ras GEF downstream of VEGF) add functional depth. ADGRG1 (GPR56) is expressed in vascular cells and regulates angiogenesis. This module represents the angiogenic/vascular guidance receptor identity of intestinal pericytes, lost during inflammation and restored in remission.
Genes
ADGRG1, CPLX1, EPHB4, KDR, MGAT4A, PLXNA2, RASGRP3, ROBO4, SLCO2A1, TMEM255B
Most correlated modules
- Basement Membrane Maintenance · correlation 0.98
- Vascular Permeability · correlation 0.98
- Rho GTPase Signaling · correlation 0.98
- BMP-SMAD Signaling · correlation 0.98
- Vascular Pericyte Identity · correlation 0.97
- Pericyte Contractile Tone · correlation 0.97
- Vascular Junction Adhesion · correlation 0.96
- YAP/TAZ Mechanosensing · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.