Pericyte Contractile Tone
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Key hub genes include NOSTRIN (eNOS trafficking regulator essential for nitric oxide production and vascular tone), PPP1R16B (myosin phosphatase targeting subunit regulating smooth muscle/pericyte contractility), LDB2 (LIM domain binding protein, vascular transcription co-factor), TMEM88 (Wnt pathway modulator), and CARD10 (NF-κB scaffold in vascular cells). PKP4 (plakophilin-4) contributes to cell junction integrity. Together these genes define a pericyte contractility and vascular tone regulatory program. Significantly downregulated in inflammation and restored in remission, consistent with loss of pericyte contractile homeostasis in IBD.
Genes
CARD10, CARD8, EHD4, FAM110D, IL27RA, KANK3, LDB2, NOSTRIN, PKP4, PPP1R16B, TMCC3, TMEM88, ZNF366
Most correlated modules
- Vascular Permeability · correlation 0.99
- Vascular Pericyte Identity · correlation 0.99
- BMP-SMAD Signaling · correlation 0.98
- Rho GTPase Signaling · correlation 0.98
- MHC-II Antigen Presentation · correlation 0.98
- Angiogenic Receptor Signaling · correlation 0.97
- Vascular Junction Adhesion · correlation 0.94
- Basement Membrane Maintenance · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.