NR2F1 — Nuclear receptor subfamily 2 group F member 1
NR2F1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NR2F1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CCL11 Secretory Fibroblast ECM production | ANK3, ARHGAP24, CCL11, COL16A1, COL18A1, DTX4, F11R, GABRA2 +5 more | View in SCUBA |
| Pericytes | Pericyte Identity Developmental | ADAMDEC1, EDIL3, EMID1, FOXF1, IL1R1, LRP1, LTBP4, MXRA5 +2 more | View in SCUBA |
| Smooth muscle cells | Fibroblast Matrisome ECM remodeling | ADAMDEC1, EMP1, FBLN1, LTBP4, PLTP, PROCR, RGS10, S100A10 +1 more | View in SCUBA |
About the gene
| Synonyms | COUP-TFI, COUPTF1, EAR-3, ERBAL3, SVP44, TCFCOUP1, TFCOUP1 |
|---|---|
| Chromosome | 5: 93583222-93594611 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Receptor, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.