LRP1 — LDL receptor related protein 1
LRP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Endocytic nutrient uptake Absorption | CDA, CREB3L2, DAB2, DNAH7, EGLN3, SLC43A2, SLC6A8 | View in SCUBA |
| Macrophages | Macrophage Endocytic Signaling Lysosomal & pahgocytosis | APLP2, ARHGAP30, ARHGEF2, ATF6B, BAG6, CLSTN1, CMTR2, CTBS +20 more | View in SCUBA |
| Pericytes | Pericyte Identity Developmental | ADAMDEC1, EDIL3, EMID1, FOXF1, IL1R1, LTBP4, MXRA5, NR2F1 +2 more | View in SCUBA |
| Smooth muscle cells | Matrix-integrin interaction ECM remodeling | C1S, EML1, FBN1, ITGA1, ITGAV, P4HA2, VMP1 | View in SCUBA |
About the gene
| Synonyms | A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R1, LRP, LRP1A |
|---|---|
| Chromosome | 12: 57128483-57213361 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Developmental protein, Receptor |
| Biological process | Endocytosis, Host-virus interaction |
Function
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2- macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Also acts as a receptor for IGFBP3 to mediate cell growth inhibition. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.