NF-kB Chemokine Response
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes: SOD2 (superoxide dismutase 2, oxidative stress/NF-kB target), TNFAIP3 (A20, NF-kB negative regulator), CXCL2, CXCL1 (neutrophil-recruiting chemokines), CCL2, CCL8 (monocyte-recruiting chemokines), NCOA7 (nuclear receptor coactivator, antiviral/interferon), PRDM1 (Blimp-1, transcriptional repressor). Significantly upregulated in both UC and CD inflammation, downregulated in remission — a strong NF-kB/chemokine inflammatory response. CXCL1, CXCL2, CCL2, CCL8 are canonical NF-kB-driven chemokines. TNFAIP3 and SOD2 are NF-kB targets. This module represents NF-kB-driven chemokine production in pericytes during intestinal inflammation. Neighbor to M45 (also inflammatory), consistent with co-regulated inflammatory programs.
Genes
CCL2, CCL8, CXCL1, CXCL2, NCOA7, PRDM1, SOD2, TNFAIP3
Most correlated modules
- Cytokine Inflammatory Response · correlation 0.76
- Stromal ECM Production · correlation 0.34
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.