SOD2 — Superoxide dismutase 2

SOD2 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SOD2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Type I Interferon Anti-viral	GBP2, GBP4, IRF9, ISG15, ISG20, LY6E, MNDA, MX1 +9 more	View in SCUBA
CD4⁺ T cells	Cytotoxic effector Cytotoxicity	ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, LYAR +11 more	View in SCUBA
Endothelial	NF-κB Activation Inflammation	C2CD4B, HSPA6, ICAM5, IER3, MAP3K8, NFKBIA, NFKBID, PMAIP1 +5 more	View in SCUBA
Fibroblasts	NF-κB Stress Response Inflammatory	EGR3, NAMPT, NCOA7, NFIL3, PHLDA1, PHLDA2, SAT1, SLC20A1 +3 more	View in SCUBA
Glial cells	NF-κB/IFN Inflammatory Inflammation	BIRC3, CTSS, CXCL10, CXCL2, CXCL9, FDCSP, HAPLN3, ICAM1 +4 more	View in SCUBA
Hematopoietic progenitor cells	Oxidative Stress Survival Stress	GMPR, KIFAP3, PIM1, RIPOR3, SH3BGRL, STON2, TAFA2
Innate lymphoid cells	AP-1 Transcriptional Activation DNA regulation & transcription	AHNAK, ALYREF, CD81, CDV3, CITED4, ESYT2, ETS1, GNAI2 +28 more	View in SCUBA
Lymphatic endothelial	NF-κB Inflammatory Activation Inflammation	ACHE, ANKLE2, CD200, CXCL1, CXCL8, HMGA1, ICOSLG, NFKB2 +9 more	View in SCUBA
Monocytes	Epigenetic Inflammatory Reprogramming Inflammatory	BHLHE40, EHD1, KDM6B, PHACTR1, PLEK, PPIF, SMAD7, ZNF267	View in SCUBA
Pericytes	NF-kB Chemokine Response Inflammatory	CCL2, CCL8, CXCL1, CXCL2, NCOA7, PRDM1, TNFAIP3	View in SCUBA
Smooth muscle cells	IFN-gamma/NF-kB Response Inflammation	ATP6V0B, CCDC71L, CFLAR, CHI3L2, EVA1B, GBP1, GBP2, HSPA8 +11 more	View in SCUBA

About the gene

Synonyms	GC1, GClnc1, IPOB, MnSOD
Chromosome	6: 159669069-159762529
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Oxidoreductase

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.