Cytokine Inflammatory Response
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes: CEBPB and CEBPD (C/EBP transcription factors, master regulators of inflammatory gene expression), SOCS1 (suppressor of cytokine signaling), ADAMTS4 (inflammatory matrix protease), RGS16 (G-protein signaling regulator, inflammation-induced), PHLDA1 (stress/apoptosis), GEM (GTPase, cytoskeletal/signaling), THBS1 (thrombospondin-1, inflammation/TGF-beta), UGCG (ceramide glycosylation), CEBPD, ID4, VMP1, KCNE4. Strongly and significantly upregulated in both UC and CD inflammation (delta ~0.5), and downregulated in remission — a classic inflammatory activation signature. CEBPB/CEBPD are canonical inflammatory transcription factors. SOCS1 is a cytokine feedback regulator. This is a coherent inflammatory activation module in pericytes.
Genes
ADAMTS4, C11orf96, CEBPB, CEBPD, GEM, ID4, KCNE4, PHLDA1, RGS16, SOCS1, THBS1, UGCG, VMP1
Most correlated modules
- NF-kB Chemokine Response · correlation 0.76
- Pericyte Inflammatory Activation · correlation 0.73
- Inflammatory ECM Remodeling · correlation 0.58
- Quiescent Pericyte State · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.