PRDM1 — PR/SET domain 1
PRDM1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRDM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated effector Tcell Immune regulation | APOBEC3C, ARPP19, CISD2, CTSC, ENTPD1, GLUD1, IL2RB, LYST +4 more | View in SCUBA |
| Endothelial | Glucocorticoid Response Inflammation | CCM2L, CFAP20, DUSP6, INAFM2, INHBB, MIER2, MYLIP, NUAK1 +6 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ATP2A2, BAMBI, C5AR2, CRISPLD2, CSNK1E, CTNNB1, DLC1, ETS2 +11 more | View in SCUBA |
| Macrophages | NF-κB Activation Inflammatory | BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Transcriptional Identity T cell maturation | AAK1, ANKRD36B, ATG16L2, BCL11B, EMB, ETS1, GOLGA8B, HNRNPUL2 +8 more | |
| Natural Killer cells | Gut-Homing NK Maturation Gut residency | ANXA2, BIN1, DHRS7, HECA, IFI27L2, ITGB7, KLF9, LGALS1 +5 more | View in SCUBA |
| Pericytes | NF-kB Chemokine Response Inflammatory | CCL2, CCL8, CXCL1, CXCL2, NCOA7, SOD2, TNFAIP3 | View in SCUBA |
About the gene
| Synonyms | BLIMP1, PRDI-BF1 |
|---|---|
| Chromosome | 6: 105993463-106109939 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Methyltransferase, Repressor, Transferase |
| Biological process | Adaptive immunity, Immunity, Innate immunity, Transcription, Transcription regulation |
Function
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue- resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta- interferon gene. Drives the maturation of B- lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.