Pericyte Identity
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes EDN1 (endothelin-1, canonical vasoactive pericyte peptide), ALPL (alkaline phosphatase, vascular pericyte marker), AIF1L (actin-organizing, pericyte cytoskeleton), STMN1 (microtubule dynamics), and LPCAT2 (lipid membrane remodeling) collectively define a quiescent pericyte identity program. The module is significantly downregulated during CD inflammation and restored in remission (delta_remission_UC=0.532), consistent with suppression of homeostatic pericyte identity during active disease. Neighbor M35 shares the same inflammation-suppressed, remission-restored pattern, reinforcing that both modules capture complementary aspects of pericyte identity.
Genes
AIF1L, ALPL, ARL15, ASRGL1, EDN1, FAM89A, GFOD1, LPCAT2, OCIAD2, STMN1
Most correlated modules
- Arterial Identity TFs · correlation 0.97
- Notch Vascular Development · correlation 0.95
- Vascular Identity TFs · correlation 0.93
- Vascular Barrier Integrity · correlation 0.92
- Arterial Pericyte Identity · correlation 0.89
- Mitochondrial OxPhos · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.