Arterial Identity TFs
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include GATA2 (master endothelial/hematopoietic transcription factor essential for vascular development), SOX17 (arterial endothelial specification TF, marks arterial identity), MECOM/EVI1 (transcription factor critical for vascular smooth muscle and endothelial identity), EPHA4 (ephrin receptor for vascular patterning), MAST4 (microtubule-associated serine/threonine kinase), PALMD (palmdelphin, cytoskeletal), FLNB (filamin B, cytoskeletal/mechanosensing), and PIK3C2B (PI3-kinase). The GATA2 + SOX17 + MECOM combination is a powerful arterial/endothelial transcription factor triad. Neighbor M73 contains EFNB2/DLL4/HEY1 (arterial Notch), making this a complementary arterial TF module to M73's arterial signaling module. Significantly downregulated in both UC and CD inflammation.
Genes
EPHA4, FLNB, GATA2, MAST4, MECOM, MTUS1, PALMD, PIK3C2B, SOX17
Most correlated modules
- Notch Vascular Development · correlation 0.98
- Pericyte Identity · correlation 0.97
- Vascular Barrier Integrity · correlation 0.97
- Vascular Identity TFs · correlation 0.96
- RAS-Chromatin Signaling · correlation 0.94
- Vascular Tone Homeostasis · correlation 0.94
- Arterial Notch Signaling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.