Vascular Barrier Integrity
Gene co-expression module in Pericytes
| Category | Migration & adhesion |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include GIMAP1/4/7 (GTPases expressed in vascular/immune contexts), JAM2 (junctional adhesion molecule critical for vascular barrier integrity), PTPRB (endothelial-specific phosphatase regulating vascular permeability), SRGN (serglycin proteoglycan), ITGB4 (integrin for basement membrane adhesion), NRN1 (neuritin, expressed in vascular cells), and MYCT1 (Myc target in endothelial cells). JAM2 and PTPRB are strong vascular barrier markers. Significantly downregulated in both UC and CD inflammation with recovery in remission, consistent with barrier disruption during IBD. Neighbor M41 also contains ICAM2 and JAG2, reinforcing a vascular barrier/junctional theme in this neighborhood.
Genes
C1orf115, FAM107A, GIMAP1, GIMAP4, GIMAP7, ITGB4, JAM2, MYCT1, NRN1, PTPRB, SRGN
Most correlated modules
- Vascular Identity TFs · correlation 0.99
- MHC-II Antigen Presentation · correlation 0.97
- Arterial Identity TFs · correlation 0.97
- Notch Vascular Development · correlation 0.96
- Vascular Pericyte Identity · correlation 0.95
- RAS-Chromatin Signaling · correlation 0.95
- Rho GTPase Signaling · correlation 0.94
- Vascular Tone Homeostasis · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.