Vascular Identity TFs
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SOX7 (SOX family TF critical for arterial/endothelial specification), HHEX (homeobox TF expressed in vascular endothelium and required for vascular development), THSD7A (thrombospondin type-1 domain protein expressed in endothelial/pericyte cells, involved in angiogenesis), TSPAN7 (tetraspanin, linking to neighbor M39), EXOC6 (exocyst complex component for vesicular trafficking), MCTP1 (calcium-sensing transmembrane protein at synapses/vascular contacts), and GIPC2 (PDZ scaffold for receptor trafficking). SOX7 and HHEX are vascular developmental transcription factors. Strongly downregulated in CD inflammation. The tetraspanin link to M39 and the TF content suggest this module captures vascular identity/specification in pericytes.
Genes
CCDC85A, EXOC6, GIPC2, HHEX, MCTP1, SLC16A14, SOX7, THSD7A, TSPAN7
Most correlated modules
- Vascular Barrier Integrity · correlation 0.99
- MHC-II Antigen Presentation · correlation 0.96
- Arterial Identity TFs · correlation 0.96
- Notch Vascular Development · correlation 0.95
- Vascular Pericyte Identity · correlation 0.94
- RAS-Chromatin Signaling · correlation 0.94
- Vascular Tone Homeostasis · correlation 0.94
- Pericyte Identity · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.