SCUBA

STMN1 — Stathmin 1

STMN1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

STMN1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsCell Cycle G1/S
Cell cycle
CARHSP1, CBX5, CENPM, DNMT1, GMNN, HMGB2, HMGN2, MND1 +8 moreView in SCUBA
CD4⁺ T cellsHypoxia metabolic stress
Stress
ARG2, ARL4D, AXIN2, BNIP3, CITED4, CNKSR2, GCA, GSTM3 +13 moreView in SCUBA
CD8⁺ T cellsMitotic Spindle
Cell cycle
ASF1B, CENPN, DDX39A, DTYMK, GGH, HMGB2, HMGN2, LMNB1 +3 moreView in SCUBA
EndothelialEndothelial NO Activation
Endothelial cell development
BCL6B, BLOC1S1, CD99, CDH13, COX5A, CREM, DDAH2, DDX46 +8 moreView in SCUBA
FibroblastsTelocyte Identity Program
Developmental
ADGRL3, ANKRD50, ARHGAP28, CLSTN2, FBLN7, FOXF1, LAMA4, PDIA5 +10 moreView in SCUBA
Glial cellsEnteric Glial Homeostasis
Housekeeping
APOE, BCHE, CCND3, COL12A1, ENTPD2, FXYD6, NPDC1, PAQR6 +5 moreView in SCUBA
Goblet cellsChromatin Organization
chromatin regulation & transcription
CBX3, HMGB1, HMGB3, HMGN1, HNRNPA2B1, PTMA, TPRKBView in SCUBA
MonocytesMitotic Cell Cycle
Cell cycle
BIRC5, CENPF, H1-5, H2AC14, MKI67, PCLAF, PTTG1, TROAPView in SCUBA
Natural Killer cellsG2/M Transition
Cell cycle
ANP32B, CARHSP1, NSD2, PHF19, SMC2, TMPO, TUBA1B, TUBBView in SCUBA
NeutrophilsMitotic Spindle
Cell cycle
ANP32B, ANP32E, DEK, H2AZ2, H4C3, HMGB1, HNRNPH1, HP1BP3 +4 more
PericytesPericyte Identity
Developmental
AIF1L, ALPL, ARL15, ASRGL1, EDN1, FAM89A, GFOD1, LPCAT2 +1 moreView in SCUBA

About the gene

SynonymsC1orf215, FLJ32206, Lag, LAP18, OP18, PP17, PP19, PR22, SMN
Chromosome1: 25884181-25906991
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Predicted intracellular proteins
Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Function

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.