Notch Vascular Development
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include HYAL2 (hyaluronidase-2, ECM hyaluronan remodeling), ADAM15 (disintegrin metalloprotease mediating cell-ECM and cell-cell adhesion), JAG2 (Notch ligand critical for vascular development), ECSCR (endothelial cell-specific chemotaxis regulator), LYL1 (bHLH TF for vascular/endothelial development), ICAM2 (endothelial adhesion molecule), ORAI1 (store-operated calcium channel), and KCNN3 (calcium-activated potassium channel). The combination of Notch ligand JAG2, endothelial TF LYL1, ECSCR, and ICAM2 points to a Notch-driven vascular development and adhesion program. Downregulated in both UC and CD inflammation. Neighbor M73 contains DLL4/HEY1/EFNB2 (arterial Notch), reinforcing the Notch vascular development theme in this neighborhood.
Genes
ADAM15, ECSCR, HYAL2, ICAM2, JAG2, KCNN3, LYL1, MANSC1, NUDT14, ORAI1, PKN3
Most correlated modules
- Arterial Identity TFs · correlation 0.98
- Vascular Tone Homeostasis · correlation 0.97
- Vascular Barrier Integrity · correlation 0.96
- Pericyte Identity · correlation 0.95
- RAS-Chromatin Signaling · correlation 0.95
- Vascular Identity TFs · correlation 0.95
- Rho GTPase Signaling · correlation 0.94
- Actin-ERM Migration · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.