RIOK3 — RIO kinase 3
RIOK3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RIOK3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, NCOR1, OGDH, SAMD9 +7 more | View in SCUBA |
| Enterocytes | Enterocyte fatty-acid catabolism Lipid metabolism | ACOX1, ACSL5, CYP3A5, GDA, MIA2, MUC3A, OGDH | View in SCUBA |
| Gamma-delta T cells | Transcription-RNA Coupling DNA/chromatin regulation | AKNA, AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1 +26 more | |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
| Monocytes | Autophagy Initiation Lysosomal & pahgocytosis | AAK1, AGFG1, ARID3B, FHIP2A, PHC2, PTK2B, TMCO3, TRABD +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Autophagy & Trafficking Stress | ATG2A, B3GNT2, BEST1, CEBPZ, CTPS1, ELOA, KANSL2, LITAF +6 more | |
| Neutrophils | NET Priming State Netosis | ADD3, APMAP, ARG1, CCDC125, CCPG1, ITGAM, PADI4, PLBD1 +1 more |
About the gene
| Synonyms | SUDD |
|---|---|
| Chromosome | 18: 23453287-23486603 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Antiviral defense, Immunity, Innate immunity, Ribosome biogenesis |
Function
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.